CAS 200630-46-2: 3-Methoxy-L-Tyrosine Monohydrate

3-O-methyl-L-DOPA, a L-DOPA metabolite from catechol O-methyltransferase, may impact or compete with L-DOPA.

Applications 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. References Soares-da Silva, P., et al.: Brain Res., 863, 293 (2000), Deleu, D., et al.: Clin. Pharmacokinet., 41, 261 (2002),

Applications Labelled 3-O-Methyl-L-DOPA (M303815). 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. References Soares-da Silva, P., et al.: Brain Res., 863, 293 (2000), Deleu, D., et al.: Clin. Pharmacokinet., 41, 261 (2002),

3-O-Methyl L-DOPA monohydrate is a chromatographic method that is used to diagnose Parkinson's disease. The method separates the catechol-o-methyltransferase (COMT) from plasma samples, which converts dopamine to 3-O-methyl dopamine. The 3-O-methyl dopamine reacts with an electrochemical detector and overlapped peaks can be seen on the chromatogram. This analytical method can be used to detect low levels of dopamine in the blood and diagnose Parkinson's disease.