CAS 20069-09-4: Piperlongumine

Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.

Piperlongumine analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Piperlongumine is a naturally occurring alkaloid, which is isolated from the fruit of the Piper longum plant. This compound has shown promise due to its selective cytotoxicity toward cancer cells. Its mode of action involves elevating reactive oxygen species (ROS) levels within cells, leading to oxidative stress that preferentially affects cancerous cells, which exhibit higher basal levels of oxidative stress compared to normal cells. The use of Piperlongumine is primarily in the research and investigation of its potential anticancer properties. Studies focus on its selective lethality against a variety of cancer types and the underlying mechanisms contributing to this effect. Researchers are particularly interested in its ability to target and selectively kill malignant cells while sparing healthy ones, offering a possible avenue for therapeutic intervention. Additionally, ongoing research explores enhancements to its efficacy and bioavailability, as well as its combinatorial effects with existing chemotherapeutic agents. Scientists continue to investigate its comprehensive range of bioactivities and establish its place in the context of cancer treatment strategies.

Piperlongumine

Stability Light Sensitive Applications Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed. References Beretz, A., et al.: Planta Med., 57, 68 (1991), Lee, S., et al.: J. Microbiol. Biotechnol., 12, 679 (2002), Lee, K., et al.: Pharmacol. Res., 53, 265 (2006),

Piperlongumine

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