CAS: 2009273-67-8

GNE-6640 is a small molecule that inhibits the ubiquitin-proteasome system. It has been shown to be effective in inhibiting tumor growth and metastasis in animal models, as well as inhibiting cell proliferation. GNE-6640 also targets the molecular pathways involved in carcinogenesis, including DNA replication and repair, protein synthesis, and other cellular processes. GNE-6640 has been shown to act as an inhibitor of acid proteases, which are involved in various cellular processes such as apoptosis and autophagy.

GNE-6640

4-(2-Amino-4-Ethyl-5-(1H-Indazol-5-Yl)Pyridin-3-Yl)Phenol

GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).