1-Hydroxy-4-aminoadamantane, also known as memantine, is a chemical compound characterized by its adamantane structure, which consists of a fused cycloalkane framework. This substance features a hydroxyl group (-OH) and an amino group (-NH2) attached to the adamantane core, contributing to its unique properties. Memantine is primarily recognized for its role as an NMDA receptor antagonist, which is significant in the treatment of neurodegenerative diseases, particularly Alzheimer's disease. The compound exhibits moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. Its pharmacological profile includes neuroprotective effects, as it helps to regulate glutamate activity in the brain, thereby preventing excitotoxicity. Memantine is typically administered in its hydrochloride salt form and is known for its relatively favorable side effect profile compared to other treatments for cognitive disorders. Additionally, it has a relatively low potential for abuse and dependency, making it a valuable therapeutic option in managing cognitive decline associated with Alzheimer's disease.

1-Hydroxy-4-aminoadamantane

20098-19-5: 2-Amino-5-hydroxyadamantane, 4-Amino-1-adamantanol, 4-Amino-tricyclo[3.3.1.13,7]decan-1-ol

Tricyclo[3.3.1.13,7]decan-1-ol, 4-amino-, hydrochloride (1:1)

4-Aminoadamantan-1-ol hydrochloride is a synthetic compound that can be synthesized by reacting methanol with hydroxylamine in the presence of a high yield salt. The salt formation and recrystallization process are required for obtaining 4-Aminoadamantan-1-ol hydrochloride. The synthesis process is patented, and the hydrogenation reduction is performed using the Raney nickel catalyst. The patent for the synthesis process has expired, and it is now commercially available.

CAS 20098-19-5: 1-Hydroxy-4-aminoadamantane

Tricyclo[3.3.1.13,7]decan-1-ol, 4-amino-, hydrochloride (1:1)

Ref: IN-DA002D4F

4-Aminoadamantan-1-ol hydrochloride

Ref: 3D-VAA09819

4-amino-1-adamantanol hydrochloride

Ref: 10-F358728