CAS 201677-59-0: (R)-N-(2-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide

The industrial synthesis of (R)-N-(2-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide has been successfully achieved using a novel process involving the use of a catalyst to generate the formylation product in high yield and enantioselectivity. This process also allows for the selective formation of the desired formylated product by using conditions that would lead to racemic products otherwise. The catalyst is a chiral, asymmetric phosphoric acid that can be combined with conventional nitrosylating agents to provide an efficient route to this target compound.