CAS: 2016806-57-6

AZ 13705339 is a potent, selective and reversible inhibitor of the ion channel TRPM8. It binds to the extracellular domain of TRPM8 and blocks the ion channel pore. AZ 13705339 is a novel tool for studying TRPM8-mediated signaling pathways in cells, as well as for developing new drugs targeting these pathways.

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.

AZ13705339