Prion Protein (118-135) (human), associated with the CAS number 202121-03-7, is a peptide fragment derived from the prion protein (PrP), which is encoded by the PRNP gene in humans. This fragment corresponds to a specific region of the full-length prion protein, which is known for its role in neurodegenerative diseases, such as Creutzfeldt-Jakob disease and other prion diseases. The peptide is characterized by its ability to adopt multiple conformations, including alpha-helical and beta-sheet structures, which are crucial for its biological function and pathogenicity. Prion proteins are typically glycosylated and can undergo post-translational modifications, influencing their stability and interactions with other cellular components. The aggregation of misfolded prion proteins is a hallmark of prion diseases, leading to neurotoxicity and the formation of amyloid plaques. Research on this peptide fragment is significant for understanding prion biology and developing therapeutic strategies against prion-related disorders.

Prion Protein (118-135) (human)

202121-03-7: H-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-Gly-Tyr-Met-Leu-Gly-Ser-Ala-Met-Ser-OH

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CAS 202121-03-7: Prion Protein (118-135) (human)

Prion Protein (118-135) (human) trifluoroacetate salt

Ref: 3D-FP109214