(D-Leu6,Pro-NHEt9)-LHRH (4-9) is a synthetic analog of luteinizing hormone-releasing hormone (LHRH), which is a peptide hormone involved in the regulation of the reproductive system. This compound features specific amino acid substitutions that enhance its stability and biological activity compared to the natural hormone. The presence of D-Leucine at position 6 contributes to increased resistance to enzymatic degradation, while the proline substitution at position 9 may influence its conformation and receptor binding affinity. The addition of an ethylamine group at the N-terminus (NHEt9) further modifies its pharmacokinetic properties, potentially improving its efficacy as a therapeutic agent. This compound is primarily studied for its potential applications in treating hormone-dependent conditions, such as certain cancers and reproductive disorders. Its unique structure allows for targeted action on the gonadotropin-releasing hormone receptor, making it a subject of interest in peptide-based drug development. As with many peptide analogs, its stability, solubility, and bioavailability are critical factors influencing its therapeutic potential.

(D-Leu6,Pro-NHEt9)-LHRH (4-9)

202333-85-5: H-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

Des-1,2,3-Leuprolide

Leuprorelin (Leuprolide) Impurity 3 Ditrifluoroacetate

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CAS 202333-85-5: (D-Leu6,Pro-NHEt9)-LHRH (4-9)

Des-1,2,3-Leuprolide

Ref: TR-L358075

Leuprorelin (Leuprolide) Impurity 3 Ditrifluoroacetate

Ref: 4Z-PL-4118

(D-Leu6,Pro-NHEt 9)-LHRH (4-9)

Ref: 3D-FL109153

(D-Leu⁶,Pro-NHEt⁹)-LHRH (4-9)

Ref: 01-4027694