CAS 202596-22-3: 2-Propen-1-one,1-[2,4-dihydroxy-3-[(1S,2E,5S)-5-hydroxy-1-(4-hydroxyphenyl)-7-phenyl-2-hepten-1-yl]-6-methoxyphenyl]-3-(4-hydroxyphenyl)-,(2E)-

Calyxin H is a naturally occurring flavonoid compound, which is isolated from the roots of Alpinia katsumadai, a plant commonly found in tropical and subtropical regions. This compound exerts its effects primarily through modulating apoptotic pathways, which involve the induction of programmed cell death in cancer cells. The mode of action of Calyxin H is characterized by its ability to interfere with mitochondrial membrane potential and activate caspase pathways, leading to cell apoptosis. The uses and applications of Calyxin H are predominantly centered around its potential as an anticancer agent. Research has shown its effectiveness against various cancer cell lines, including breast and prostate cancer, by targeting specific cellular pathways that regulate cancer cell survival and proliferation. Moreover, studies are exploring its synergistic effects when combined with other chemotherapeutic agents, potentially enhancing efficacy and reducing dosage requirements. As such, Calyxin H holds promise for incorporation into future oncological therapeutic strategies, though further studies are required to fully elucidate its safety profile and mechanism of action.

Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.