CAS: 202808-11-5

MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki

MRZ 2/514 is a methoxy-substituted glycine derivative that is used as an antagonist. It has been shown to function as a competitive antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor, which is involved in neurotransmission. MRZ 2/514 has also been shown to block excitotoxicity in mice, which is caused by excessive stimulation of glutamate receptors. The methoxy group on MRZ 2/514 can be converted into a pyridyl group, which can form a dione with the amino acid histidine. This dione can then react with nitric oxide to form a nitrosated species that inhibits the activity of NMDA receptors.

MRZ 2-514