CAS 2032-34-0: 3,3-Diethoxypropionitrile

Applications 3,3-Diethoxypropionitrile is a propionitrile derivative used in the preparation of various biologically active compounds such as p38α mitogen-activated protein kinase inhibitors. References Goldstein, D.M. et al.: J. Med. Chem., 54, 2255 (2011);

3,3-Diethoxypropionitrile (3,3-DEP) is a synthetic compound that has been shown to have high specificity for terminal alkynes. It is activated by hydrochloric acid and reacts with terminal alkynes in a reaction mechanism that starts with the formation of an acetaldehyde intermediate. The reaction system is catalyzed by an acidic catalyst, such as HCl or HBr. 3,3-DEP can be used in the synthesis of a number of pharmaceuticals, including bosutinib. This drug inhibits the growth of cells that are resistant to other treatments, such as c1-c3.

3,3-Diethoxypropanenitrile