CAS 20605-01-0: Diethyl bis(hydroxymethyl)malonate

Diethyl bis(hydroxymethyl)malonate is a bioconjugate that can be used as a nucleophile in synthetic chemistry. It has been used to synthesize ethylene diamine, which is an important raw material for the production of nylon. Diethyl bis(hydroxymethyl)malonate can also be used in the synthesis of malonic acid, which is an important chemical intermediate. The systematic name for this compound is diethyl (hydroxymethyl)malonate. Diethyl bis(hydroxymethyl)malonate has two structural isomers: cis and trans. The cis-isomer has a higher affinity for binder molecules than the trans-isomer does, so it may be advantageous to use the cis-isomer in binding applications.

Diethyl 2,2-bis(hydroxymethyl)malonate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethyl bis(hydroxymethyl)malonate is used as a reagent for preparing 1,3-dioxanes from acetals, aldehydes and ketones. It is also used as an intermediate for the preparation of substituted malonic, acrylic and isobutyric esters, for conversion to the useful dienophiles, ?-bromomethylacrylic acid and its ethyl ester and to bis(bromomethyl)acetic acid and its methyl ester. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.