CAS 206645-99-0: Compstatin

Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.

Compstatin, ICVVQDWGHHRCT, is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3.

Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt is a cyclic peptide with antiangiogenic and anticancer properties. Compstatin is an analog of a human serum albumin protein, which has been shown to have significant cytotoxicity in vivo. The analog has been shown to bind to the endothelial cell receptor, inhibiting angiogenesis. This drug also inhibits cancer cell proliferation by interfering with the synthesis of DNA and RNA. Compstatin trifluoroacetate salt H-Ile-Cys-Val -Val -Gln -Asp -Trp -Gly -His -His -Arg -Cys -Thr NH2 trifluoroacetate salt (disulfide bond) can be synthesized in