CAS: 206978-14-5

Lactone

Epoxybergamottin is a furanocoumarin derivative, which is a natural bioactive compound. It is primarily sourced from citrus fruits, particularly grapefruit. The primary mode of action of epoxybergamottin is the inhibition of cytochrome P450 enzymes, specifically CYP3A4. This enzyme is a major player in the metabolism of many pharmaceuticals, and its inhibition can lead to increased bioavailability and prolonged effects of drugs metabolized by this pathway. The uses and applications of epoxybergamottin are primarily in pharmacokinetic studies. It serves as a tool for understanding drug interactions and metabolism, aiding in the development of safer pharmaceutical regimens. Epoxybergamottin is also used in research to explore the effects of dietary components on drug efficacy and safety, highlighting its significance in both drug development and nutritional science. By studying compounds like epoxybergamottin, scientists can better predict and manage potential adverse effects that may arise from the consumption of certain foods during drug therapy.

6'7'-Epoxybergamottin: Found in grapefruit; inhibits CYP3A4 (IC50: 0.30 ppm); presents in juice (0.1-7.4 μM); blocks talinolol transport; is insecticidal.