CAS: 2070009-26-4

pGlu-Pro-Arg-MNA monoacetate: a thrombin substrate mimicking fibrinogen for assays of antithrombin III.

Pglu-Pro-Arg-mna monoacetate is a synthetic peptide inhibitor, which is typically derived from biochemical synthesis processes involving solid-phase peptide synthesis. Its primary mode of action is the competitive inhibition of certain enzyme activities, commonly within the realm of proteolytic enzymes. By mimicking substrate structures, it effectively binds to the enzyme's active site, thereby preventing the actual substrate from interacting and consequently inhibiting the enzyme's activity. This peptide is extensively used in biochemical and pharmacological research to study enzyme mechanisms, particularly those involved in disease pathways. Its applications include enzyme kinetic studies, inhibitor screenings, and as a tool in structural biology for elucidating enzyme-substrate interactions. The utilization of Pglu-Pro-Arg-mna monoacetate can provide critical insights into therapeutic target validations and drug development processes, contributing to advancements in medical sciences and biotechnological innovations.