CAS: 207446-83-1

Arteannuin H is a sesquiterpene lactone, which is derived from the plant Artemisia annua, commonly known as sweet wormwood. This compound is part of the artemisinin family, renowned for its medicinal properties. The source, Artemisia annua, is a plant that has been used in traditional Chinese medicine for centuries, primarily for its effectiveness against fever. The mode of action of Arteannuin H involves the generation of reactive oxygen species, which results in oxidative stress that targets the parasite's biomolecules, leading to its death. This mechanism is particularly effective against the Plasmodium species, responsible for malaria. The endoperoxide bridge in its chemical structure is critical for its therapeutic efficacy, as it interacts with iron within the parasite, leading to cellular damage. Arteannuin H is primarily utilized in antimalarial treatments, forming a crucial component of artemisinin-based combination therapies. Its application extends to research settings where it serves as a model compound to study antimalarial activity and resistance mechanisms. Scientists are also exploring its potential in treating other diseases, leveraging its oxidative stress-inducing capabilities.