CAS: 2074607-48-8

2-(5-Phenyl-4-(Pyridin-4-yl)-1H-1,2,3-Triazol-1-yl)-N-(5-phenylPyridin-2-yl)Acetamide

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

IWP-O1 is a small molecule inhibitor designed to target the Wnt signaling pathway, which is pivotal in regulating key processes in cellular development and growth. This compound is derived through synthetic chemistry, crafted to bind specifically to Porcupine, an O-acyltransferase essential for Wnt protein secretion. By inhibiting Porcupine, IWP-O1 effectively disrupts the downstream activity of Wnt ligands, offering precise control over Wnt-dependent signaling cascades. This compound is widely used in scientific research to study Wnt-related mechanisms in various biological contexts, including embryogenesis, stem cell differentiation, and cancer progression. Researchers apply IWP-O1 to elucidate pathway-specific roles and to manipulate gene expression influenced by Wnt signaling. Its precise inhibition of Porcupine makes it invaluable in dissecting cellular responses and in developing potential therapeutic interventions targeting aberrant Wnt activity.

IWP-O1