5-Nitrooxindole is an organic compound characterized by its oxindole structure, which is a bicyclic compound containing both an indole and a ketone functional group. The presence of a nitro group at the 5-position of the oxindole ring contributes to its unique chemical properties, including increased reactivity and potential for various chemical transformations. This compound is typically a yellow to orange solid, and it is sparingly soluble in water but more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). 5-Nitrooxindole is of interest in medicinal chemistry due to its potential biological activities, including antimicrobial and anticancer properties. Its reactivity allows it to participate in various synthetic reactions, making it a valuable intermediate in the synthesis of more complex molecules. As with many nitro compounds, care should be taken when handling 5-nitrooxindole due to its potential toxicity and environmental impact. Proper safety protocols should be followed to mitigate any risks associated with its use in laboratory settings.

5-Nitrooxindole

20870-79-5: 5-Nitro-2-oxindole, 5-Nitroindolin-2-One, 5-nitro-1,3-dihydro-2H-indol-2-one, 5-Nitrooxidole

5-Nitro-2-oxy indole is a mitochondrial inhibitor that inhibits the production of ATP and glucose by inhibiting β-unsaturated ketone reductase. It has been shown to be cytotoxic in vitro against cancer cells, but is not active against bacteria. 5-Nitro-2-oxy indole has also been shown to inhibit the activity of serine proteases, which are enzymes involved in inflammation and other diseases. 5-Nitro-2-oxy indole binds to the active site of serine proteases with a pharmacophore similar to that of other inhibitors. This binding prevents the enzyme from binding a specific substrate, such as tyrosine kinase or ammonium nitrate, and prevents activation of the enzyme.

CAS 20870-79-5: 5-Nitrooxindole

5-Nitro-2-oxy indole

Ref: 3D-FN57646

2H-Indol-2-one, 1,3-dihydro-5-nitro-

Ref: IN-DA002JUO

5-Nitro-2-oxindole

Ref: 54-OR10569

5-Nitroindolin-2-one

Ref: 10-F216514