CAS: 2095417-11-9

4,5-Didehydro-2'-O-methyl-5'-methyluridine (4,5-DdUMP) is a monophosphate nucleoside that has antiviral and anticancer properties. It is an activator of DNA polymerase alpha and can be used to synthesize DNA. 4,5-DdUMP is a precursor to the nucleosides in the synthesis of deoxyribonucleic acid (DNA). This compound also inhibits DNA gyrase and topoisomerase IV. 4,5-DdUMP has been shown to be active against HIV, herpes simplex virus type 1 (HSV1), HSV type 2 (HSV2), human cytomegalovirus (CMV), Epstein Barr virus (EBV), influenza A virus, vesicular stomatitis virus (VSV), mouse leukemia L1210 cells, and human leukemia HL60 cells. It also inhibits proliferation of tumor

Nucleoside Derivatives - 5’-Modified nucleosides, Didehydro-nucleosides, 2’-Modified nucleosides