CAS: 2097136-42-8

(3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is an alkaloid compound, which is characterized by its complex polycyclic structure. Derived from natural sources such as plant species or synthesized through advanced organic chemistry techniques, this compound demonstrates potential through its complex pharmacodynamics. It exhibits activity by interacting with specific biological receptors, influencing signal transduction pathways, and modulating enzyme activities, thereby eliciting a variety of physiological responses. In scientific research, (3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is primarily explored for its pharmacological applications, possibly offering therapeutic benefits in areas such as oncology or neurology. Its ability to modulate cellular and molecular mechanisms makes it a point of interest in drug development and medicinal chemistry. Ongoing studies aim to elucidate its full spectrum of biological activities, safety profile, and therapeutic potential for future clinical applications.

(S)-3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (-)-blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S)-3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm). It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 µM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 µM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (-)-blebbistatin enantiomer in mechanism and efficacy.