CAS 20977-05-3: Escin monosodium salt

Aescin polysulphate sodium salt is a synthetic anti-inflammatory compound, designed as an enhanced version of the natural saponin, aescin, derived from horse chestnut seeds (Aesculus hippocastanum). The modification to create the polysulphate sodium salt increases the solubility and bioavailability of the compound, facilitating its absorption and effectiveness in biological systems. The primary mode of action involves the stabilization of capillary walls and the inhibition of the action of certain enzymes that degrade connective tissues, which helps reduce inflammation and edema. This molecular interaction is crucial in various therapeutic contexts, making it a valuable agent in treating conditions that involve excessive fluid retention and swelling. Aescin polysulphate sodium salt finds applications predominantly in the medical and pharmaceutical industries for the management of chronic venous insufficiency, hemorrhoids, and post-operative edema. Ongoing research is expanding its potential applications, focusing on its impact on microcirculation improvement and its anti-inflammatory properties, potentially benefiting a range of pathophysiological conditions involving edema and inflammation.

Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.

Aescin monosodium salt is a semisynthetic, anti-inflammatory product derived from escin, which is a mixture of saponins extracted from horse chestnut seeds (Aesculus hippocastanum). It functions primarily by enhancing the integrity of venous walls and decreasing vascular permeability. This is achieved through the stabilization of lysosomal membranes and the inhibition of enzymes that contribute to the breakdown of the vascular endothelium, as well as promoting the release of prostaglandins with vasoprotective properties. Aescin monosodium salt is utilized in scientific research and medicinal applications for its efficacy in treating conditions associated with impaired venous circulation and edema. It is often applied in studies focusing on chronic venous insufficiency, varicose veins, and in reducing postoperative or traumatic swelling. Its roles in modulating inflammatory responses and improving capillary resistance make it a valuable compound in exploring cardiovascular and anti-inflammatory therapeutics.