CAS: 2097971-01-0

PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.

Protac BRD9 Degrader-1 is a small molecule degrader, which is a bifunctional molecule derived from proteolysis-targeting chimera (PROTAC) technology. It operates by harnessing the ubiquitin-proteasome system to selectively degrade the BRD9 protein. The molecule consists of two ligands: one binds to the target protein, BRD9, and the other recruits an E3 ubiquitin ligase. This forms a ternary complex, leading to the ubiquitination and subsequent degradation of BRD9. The use of Protac BRD9 Degrader-1 is primarily in research settings, where it serves as a tool to study the biological functions of BRD9 by providing a method for conditional and reversible protein knockdown. It is particularly useful in studying epigenetic regulation, as BRD9 is part of the SWI/SNF chromatin remodeling complex. This degrader allows researchers to investigate the roles of BRD9 in various diseases, including cancer, by exploring how its absence affects cellular processes. The specificity and efficacy of Protac BRD9 Degrader-1 make it a powerful tool for dissecting complex biological pathways and understanding disease mechanisms at a molecular level.