CAS: 2098902-68-0

KDM4D-IN-1

KDM4D-IN-1 is a chemical compound that acts as a selective inhibitor. It is derived synthetically to target the KDM4D enzyme, a member of the Jumonji family of histone demethylases. The mode of action involves the inhibition of the catalytic activity of KDM4D, which regulates the demethylation of lysine residues on histones, specifically demethylating H3K9me3/me2. This regulation plays a significant role in chromatin remodeling and gene expression. The primary use of KDM4D-IN-1 is in experimental settings where modulation of histone methylation status is required to study gene regulation mechanisms and epigenetic control. It is utilized extensively in oncological research to understand the epigenetic alterations associated with cancer progression and to explore potential therapeutic avenues for targeting aberrant histone methylation. KDM4D-IN-1 is also valuable in developmental biology studies where precise control of gene expression is crucial. This compound serves as a tool in probing the biological roles of KDM4D and related histone demethylases in various cellular processes.

KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).