CAS: 2108806-02-4

Jnj-37822681 dihydrochloride is a research tool that inhibits ion channels, ligand-gated ion channels, and G protein-coupled receptors. It has been shown to activate or inhibit ion channels in cell culture and animal models. Jnj-37822681 dihydrochloride has also been found to be a potent inhibitor of Kv1.2, a voltage-gated potassium channel. This compound has been used as a pharmacological tool for the study of ligand binding to peptides and receptors in vitro.

JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的,可快速解离的多巴胺 D2受体拮抗剂,与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。