CAS: 210980-68-0

Impurity Simvastatin EP Impurity C Applications Dehydro Simvastatin (Simvastatin EP Impurity C) is a Simvastatin (S485000) impurity. References Carlucci, G., et al.: J. Pharm. Biomed. Anal., 10, 693 (1992), Nagarajan, R., et al.: Langmuir, 16, 6400 (2000), Wang, L., et al.: J. Pharm. Biomed. Anal., 21, 1243 (2000),

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Anhydrosimvastatin

Dehydro simvastatin is a high-yielding, efficient, and selective synthesis of simvastatin. It is prepared from the commercially available (2S)-2-[(1E,3R)-3-hydroxybut-1-enyl]oxirane using a three-component reaction with chlorotrimethylsilane and sodium chloride to yield the desired product in good yields. The reaction can be performed in a variety of solvents including dichloromethane, chloroform, tetrahydrofuran, or methanol. Dehydro simvastatin has been used for pharmaceutical formulations as an active ingredient of HMG CoA reductase inhibitors. It also has been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis.

Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.