CAS: 2134096-03-8

Almonertinib hydrochloride

N-(5-((4-(1-Cyclopropyl-1H-Indol-3-Yl)Pyrimidin-2-Yl)Amino)-2-((2-(Dimethylamino)Ethyl)(Methyl)Amino)-4-Methoxyphenyl)Acrylamide Hydrochloride

Almonertinib hydrochloride is a potent and selective small molecule inhibitor of receptor tyrosine kinase (RTK) signaling. Almonertinib hydrochloride binds to the ATP-binding pocket of RTKs, blocking activation and downstream signaling by preventing phosphorylation by tyrosine kinases. Almonertinib hydrochloride exhibits high selectivity for RTKs over other kinases, which makes it ideal for research into receptor-ligand interactions.

Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.