CAS 21499-24-1: Agrimonolide

Agrimonolide is a bioactive compound, classified as a natural sesquiterpene lactone. It is derived primarily from the plant Agrimonia pilosa, a member of the Rosaceae family. This compound has garnered interest due to its multifaceted biological properties, acting primarily through modulation of various cellular signaling pathways. Agrimonolide's mode of action involves the inhibition of pro-inflammatory mediators and modulation of oxidative stress markers. It acts by interfering with the nuclear factor-kappa B (NF-kB) signaling pathway, which plays a crucial role in inflammatory responses and immune functions. Additionally, agrimonolide exhibits antioxidant activity, scavenging free radicals and reducing oxidative damage at the cellular level. The uses and applications of agrimonolide are diverse, encompassing potential therapeutic roles in the treatment of inflammatory diseases, cancer, and as a neuroprotective agent. Its anti-inflammatory and antioxidant properties make it a promising candidate for further pharmaceutical development and integrative medicine research. Despite its promising bioactivity, further studies are required to elucidate its complete pharmacokinetics and therapeutic efficacy in clinical settings.

Agrimonolide, from Agrimonia pilosa, has anti-inflammatory, antidiabetic, anticancer effects, crosses blood-brain barrier.