CAS: 2172617-15-9

YKL-06-061

YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.

YKL-06-061 is a small molecule inhibitor, which is designed to target the chitinase enzyme family, specifically inhibiting the activity of glycoside hydrolase enzymes. This product is synthesized chemically, often utilized in biochemical research settings. Through competitive inhibition, YKL-06-061 binds to the active site of the enzyme, thereby blocking the hydrolysis of chitin into N-acetylglucosamine units. This mode of action makes it a valuable tool for studying the regulation and function of chitinases in various biological processes. In research, YKL-06-061 is employed to elucidate the roles of chitinases in pathophysiological conditions, including inflammatory diseases and infections where chitin metabolism plays a critical part. Its ability to selectively inhibit specific enzymes provides insight into the chitinase-mediated pathways and affords the opportunity to explore potential therapeutic implications in diseases where chitinase expression is dysregulated.

1-Cyclobutyl-3-(2,6-Dimethylphenyl)-7-((2-Methoxy-4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-3,4-Dihydropyrimido[4,5-d]Pyrimidin-2(1H)-One