CAS 21770-81-0: 1-Methylguanidine hydrochloride

Methylguanidine HCl is a denaturing agent that can be used in the analysis of organic substances. It is used to study the biological properties of nitrogen-containing molecules, such as peroneal nerve. Methylguanidine HCl has been shown to have anti-inflammatory activity and can be used as an analgesic. Methylguanidine HCl binds to the ionotropic glutamate receptors, which are chloride channels, and this binding leads to an increase in intracellular chloride concentrations. This effect on chloride ions may be responsible for its ability to reduce pain sensation. Methylguanidine HCl also has a modulating effect on the synthesis of creatine and nitric oxide in serum levels.

1-Methylguanidine Hydrochloride

MG derived from protein breakdown, may be toxic in renal failure but has anti-inflammatory properties, inhibiting iNOS and TNF- release.

Stability Hygroscopic Applications N-Methylguanidine is an alkylated guanidine which shows inhibitory action against trypsin catalysis. N-Methylguanidine inhibited metabolism of certain hepatic drugs that was mediated by cytochrome P 450 protein in human liver microsome and hepatocyte. References Inagami, T. et al.: Biochemistry, 7, 4045 (1968); Hanada, K. et al.: Nephron, 103, 179 (2006);

1-Methylguanidine hydrochloride

Methylguanidine hydrochloride can be used in the synthesis of biaryl derivatives which were evaluated as BACE1 inhibitors. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.