CAS: 2183470-09-7

GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).

GCN2-IN-6

GCN2-IN-6 is a potent and selective activator of the GCN2 protein kinase. GCN2 is a serine/threonine protein kinase that phosphorylates eIF2α, leading to an increase in protein synthesis. The GCN2-IN-6 peptide can be used as a research tool to investigate the role of GCN2 in cell biology and for the study of ion channels, peptides and antibodies. GCN2-IN-6 has been shown to inhibit antibody production by inhibiting protein interactions with B cells and macrophages, which are important for antibody production.