CAS 21879-81-2: (5S,6R,7S)-5,6,7,8-Tetrahydro-5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-1,4-anthracenedione

Bostrycin is a polyketide-type natural product, which is a secondary metabolite produced by certain fungi, particularly those belonging to the genus Aschersonia. Its source lies in the complex biosynthetic pathways of these fungi, which synthesize diverse polyketides with bioactive properties. The mode of action of Bostrycin involves disrupting cellular processes, predominantly through the inhibition of specific enzyme activities and interference with DNA processes, which can lead to cell cycle arrest and apoptosis in target cells. In research settings, Bostrycin has garnered interest due to its potential applications in pharmacology, particularly for its anticancer and antibiotic properties. Studies have shown its capacity to modulate cellular responses and inhibit the growth of various cancer cell lines. Furthermore, its antibiotic activity has been explored against several bacterial strains, indicating a potential role in developing new therapeutic agents. While its precise mechanisms continue to be investigated, Bostrycin represents a promising candidate for further study in drug development and biochemical research.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.