CAS 21948-70-9: 2-(Methylthio)pyrazine

2-(Methylthio)pyrazine

2-(Methylthio)pyrazine is an antibacterial agent that binds to the target site, which is an enzyme called DNA gyrase. 2-(Methylthio)pyrazine inhibits the growth of bacteria by causing a break in the DNA strand and prevents it from replicating. The inhibitory activity of 2-(methylthio)pyrazine has been shown in a number of bacterial strains, including Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Staphylococcus aureus and Salmonella enterica. The reaction solution was prepared by adding 0.1 mL of ligand (2-(methylthio)pyrazine), 0.5 mL of reaction solution (buffer solution), and 1 mL of nitrogen gas to a test tube with 5 mL of water at room temperature for 5 minutes. The linear regression analysis showed a positive correlation between concentration and inhibition rate.