CAS 220246-81-1: Acetamide,N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-

Applications A metabolite of Levosimendan (L378000). References Rubinstein, A., et al.: J. Pharmacol. Met., 19, 213, (1988), Pollesello, P., et al.: J. Biol. Chem., 269, 28584(1994), Yokoshiki, H., et al.: Eur. J. Pharmacol., 333, 249 (1997)

OR-1896 is a PDE III inhibitor, a vasodilator with partial anti-inflammatory properties, and can be used to study heart failure and vascular dysfunction.

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone is a potent antihypertensive drug that belongs to the class of pyridazines. It is a research chemical and has been shown to have vasorelaxant properties in rat thoracic tissue. This compound has substituents on the nitrogen atom and can exist as a zwitterion in aqueous solution. The nucleus of this compound is an azepine ring, which contains two carbons and two nitrogens. (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone has bioisosteres with senazodan. Clinical trials are ongoing for the use of this compound as an antihypertensive agent

OR-1896