CAS 220904-83-6: 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one

3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.

Raf1 Kinase Inhibitor I is a small molecule inhibitor, which is synthetically derived to target the Raf1 kinase enzyme specifically. It operates by intervening in the kinase signaling pathways, particularly inhibiting the activity of Raf1 kinase, which is part of the MAPK/ERK pathway. This effectively impedes the downstream phosphorylation processes that are crucial for cell proliferation and differentiation. The inhibitor is primarily used in research to explore the complexities of Raf1 kinase's role within cellular signaling and to decipher the pathway's contribution to various cancer types and other proliferative diseases. By halting the Raf1 kinase activity, scientists can better understand the dynamics of cell signaling and develop potential therapeutic strategies. Raf1 Kinase Inhibitor I is also employed to explore resistance mechanisms in cancer therapies, providing insights into more effective combinatory treatments. Its application facilitates a deeper understanding of the intricate molecular mechanisms driving various pathological conditions.

GW 5074