CAS: 222318-55-0

(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in

(4E)-SUN9221 is a peptide that binds to the extracellular domain of the human N-methyl-D-aspartate receptor (NMDAR) and inhibits its activity. It has been shown to be a potent inhibitor of NMDARs in neuronal cells, and also inhibits the binding of glutamate to the receptor. This peptide may provide insight into understanding how NMDA receptors regulate neuronal activity and may help develop new treatments for neurodegenerative diseases such as Alzheimer's disease.