CAS: 2225938-17-8

MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).

6-(6-(4-(2-(2-(Adamantan-1-Yl)Acetamido)Ethyl)Piperazin-1-Yl)Pyridin-3-Yl)-N-((4,6-Dimethyl-2-Oxo-1,2-Dihydropyridin-3-Yl)Methyl)-1-Isopropyl-1H-Indazole-4-Carboxamide

MS1943 is a monoclonal antibody that binds to the HER2 receptor and inhibits the growth of breast cancer cells. MS1943 is currently in clinical trials for its potential use as a biomarker in patients with HER2+ breast cancer. The drug has been shown to bind to a variety of targets, including response elements and intracellular targets. It also binds to both the extracellular domain of the HER2 receptor and the intracellular domain of the HER2 receptor. MS1943 binds to many different subunits, including dimeric forms of HER2 receptors, which may be responsible for its success against certain types of breast cancers.

MS1943