CAS: 2227149-22-4

DS18561882 is a mitochondria-targeting drug that can induce apoptotic cell death. It has been shown to be clinically relevant in phase II clinical studies. DS18561882 may be used as a prognostic marker for cancer patients, and it suppresses the expression of genes that promote cell proliferation. This drug also inhibits protein synthesis, which causes apoptosis by targeting the mitochondria. DS18561882 is orally active and can be used as an anticancer agent against solid tumors.

DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.

DS18561882