CAS: 222716-34-9

Stability Hygroscopic Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase. References Chan, C., et al.: Cell, 154, 556-568 (2013)

SZL P1-41

SZL P1-41 inhibits Skp2, blocks complex formation, and halts ubiquitination, promoting cell senescence, reducing glycolysis, and exhibiting antitumor effects.

SZL P1-41 is a secretase inhibitor that inhibits the activity of ubiquitin ligases. It has been shown to inhibit the progress of Alzheimer's disease in wild-type mice, and it also inhibits cell growth and proliferation in prostate cancer cells. SZL P1-41 inhibits the fibrillization of amyloid protein by preventing its binding to other proteins, which decreases the production of beta-amyloid peptides. This drug is currently being investigated as a potential anticancer agent due to its ability to inhibit cell cycle progression and induce apoptosis.

3-(Benzo[D]Thiazol-2-Yl)-6-Ethyl-7-Hydroxy-8-(Piperidin-1-Ylmethyl)-4H-Chromen-4-One