CAS: 2230731-99-2

KDOAM-25 is a selective antagonist of the Kv1.3 ion channel. It binds to the extracellular domain of the channel and prevents it from opening, thereby blocking potassium ions from entering the cell and preventing action potentials. KDOAM-25 has been shown to inhibit receptor-mediated calcium influx, which is involved in many cellular functions such as neurotransmitter release, gene expression, and cell death. This drug also has an affinity for other ion channels and may be used as a research tool for studying ion channels.

KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).