CAS: 2250019-92-0

AMG 18 hydrochloride is an immune response modifier that inhibits the production of melanin by cells. It is a modulator of immunity and downregulates or upregulates the inflammatory response. AMG 18 hydrochloride has been shown to be a potent inhibitor of hyperpigmentation in mice, which was reversed with the administration of a blocker of the immune response. This drug also modulates pigmentation in human skin in vivo by inhibiting melanin synthesis.

Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.