CAS 22608-11-3: Demethoxycurcumin

Ketone-phenols and ketones with other oxygen function

Demethoxycurcumin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Demethoxycurcumin

Ketone phenol

Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine, has anti-inflammation and anti-cancer activities, the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-κB in MDA-MB-231 cells.

Applications The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ryu, M.J. et al.: Biochem. Biophys. Res. Comm., 377, 1304 (2008); Sandur, S.K. et al.: Carcinogenesis, 28, 1765 (2007); Huang, T. et al.: J. Agric. Food. Chem., 58, 10639 (2010);

Demethoxycurcumin is a natural bioactive compound, which is a type of curcuminoid. It is derived from the rhizomes of the plant Curcuma longa, commonly known as turmeric, a member of the ginger family. Demethoxycurcumin is one of the primary components contributing to the characteristic yellow color of turmeric. The mode of action of Demethoxycurcumin involves its ability to modulate various biochemical pathways. It exhibits strong antioxidant activity by scavenging free radicals and enhancing cellular antioxidant defenses. This compound is also known for its anti-inflammatory properties, achieved through the inhibition of pro-inflammatory mediators and modulation of the nuclear factor-kappa B (NF-κB) signaling pathway. Demethoxycurcumin is extensively studied for its potential applications in health and medicine, particularly in preventing and treating conditions associated with oxidative stress and inflammation, such as cancer, cardiovascular diseases, and neurodegenerative disorders. Additionally, it serves as a valuable compound in the study of natural product chemistry and drug development, as researchers continue to explore its therapeutic potential and mechanisms.

(1E,6E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-Hydroxyphenyl)Hepta-1,6-Diene-3,5-Dione

Demethoxycurcumin: antioxidant, anti-inflammatory, anti-proliferative, anti-acanthamoebic, enhances chemo for resistant cancers, inhibits cancer pathways.