CAS 22677-21-0: (R)-4-hydroxy-2-pyrrolidone

(R)-(+)-4-Hydroxy-2-pyrrolidinone is a synthesized chiral compound that has been shown to have antibacterial properties. It has been shown to be active against Escherichia coli and Enterococcus faecalis, among others. The synthesis of this compound was achieved by the reaction of acetonitrile with γ-aminobutyric acid in a ternary phase. The biological activity of (R)-(+)-4-hydroxy-2-pyrrolidinone was confirmed by FTIR spectra and fluorescence data obtained from carnitine and ornithine. This compound is comprised of two subunits, an amide group and carbonyl group. Thermodynamic data for the synthesis of (R)-(+)-4-hydroxy-2-pyrrolidinone were also obtained.br>

(R)-(+)-4-Hydroxy-2-pyrrolidinone

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Applications The (R)-enantiomer intermediate in the preparation of Oxiracetam (O846905). References Kondepudi, D., et al.: Science, 250 975 (1990), Di Silvestro, G., et al.: J. Pharm. Sci., 82, 758 (1993),