CAS 2276-94-0: (3α,5α)-3-Hydroxycholan-24-oic acid

Applications Allolithocholic acid is used as steroid compound as T regulatory lymphocyte modulators and uses for treatment of inflammatory or autoimmune disorders. References Littman, D. R., et al.: PCT Int. Appl. 160pp. (2020)

Allolithocholic acid (allo-LCA) is found in the urine of infants with biliary atresia and promotes intestinal and hepatic metabolism.

Allolithocholic acid is a secondary bile acid, which is derived from the microbial metabolism of primary bile acids within the intestinal tract. Its mode of action involves interactions with nuclear receptors and membrane-bound receptors that regulate various metabolic pathways, including lipid metabolism and glucose homeostasis. These interactions suggest its potential to influence cholesterol levels and glycemic control. The uses and applications of Allolithocholic acid are primarily in the realm of research focused on metabolic disorders, such as diabetes and atherosclerosis. It serves as a model compound in studies examining the impact of bile acids on metabolic regulation, offering insights into the development of novel therapeutic strategies. Moreover, its role in modulating gut microbiota compositions and functions offers further avenues for investigation, particularly concerning gastrointestinal health and related systemic effects.