CAS 22864-92-2: 1-[(13S)-1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl]propan-2-one

6-Acetonyldihydrochelerythrine is a synthetic derivative of the natural alkaloid dihydrochelerythrine, which is typically sourced from plants in the Papaveraceae family, such as Chelidonium majus. This compound belongs to the benzophenanthridine alkaloids, known for their bioactive properties. The modification at the acetone site is intended to alter its solubility, stability, or interactions with biological targets. The mode of action of 6-Acetonyldihydrochelerythrine is potentially linked to its ability to interact with biological membranes and proteins, modulating cellular pathways relevant in pharmacological contexts. Its underlying molecular mechanisms could involve enzyme inhibition or interaction with DNA, although specific pathways may vary and require further elucidation. In scientific research, 6-Acetonyldihydrochelerythrine might be employed in studies investigating cell signaling, apoptosis, or as a lead compound in drug development. Its diverse biological activities could provide insights into novel therapeutic strategies, particularly in oncology or antimicrobial research, where benzophenanthridine alkaloids have previously shown promise. The compound's role as a chemical probe could aid in elucidating cellular processes, offering potential applications across various fields of biomedical research.

6-Acetonyldihydrochelerythrine: anti-HIV, antioxidant, induces apoptosis, cytotoxic to HCT116/SW620 cells, more effective than 5-FU. EC50=1.77µg/mL, TI=14.6.