CAS: 2304549-73-1

GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).

GFB-8438

GFB-8438 is a molecule that is structurally similar to the non-selective cation channel blocker, amiloride. GFB-8438 blocks the uptake of ions from the cytoplasm into organelles and may be useful in treating virus infections and cancers. It has been shown to inhibit coronaviruses and other viruses that use ion channels for cellular entry. GFB-8438 also inhibits cation channels in cells, which are important for cell function, highlighting its potential as a cancer drug.