CAS: 2304947-71-3
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4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-Carboxamide
CAS:4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-CarboxamidePurity:98%Molecular weight:541.18g/molTH 5487
CAS:Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.Formula:C19BrH18IN4O2Purity:Min. 95%Color and Shape:SolidMolecular weight:541.18 g/molTH5487
CAS:TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)Formula:C19H18BrIN4O2Purity:96.77% - 98.73%Color and Shape:SolidMolecular weight:541.18Ref: TM-T8119
1mg48.00€2mg63.00€5mg94.00€10mg160.00€25mg304.00€50mg550.00€100mg792.00€500mg1,605.00€1mL*10mM (DMSO)111.00€
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