CAS 2305-32-0: (±)-trans-1,2-Cyclohexanedicarboxylic acid

Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain. References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

trans-1,2-Cyclohexanedicarboxylic Acid

Trans-1,2-Cyclohexane dicarboxylic acid is a cyclic dicarboxylic acid that has a carboxylate group. It is an enantiopure compound because it contains only one chiral center. Trans-1,2-Cyclohexane dicarboxylic acid is used in the synthesis of amines and malic acid, which is used in food processing as a preservative or for flavor enhancement. Trans-1,2-Cyclohexane dicarboxylic acid can also be found in some pharmaceuticals that are used to treat disorders involving the central nervous system. Trans-1,2-Cyclohexane dicarboxylic acid has been shown to have low energy barriers for reactions involving its carbonyl group, which makes it an optimal candidate for reactions with other carbonyl groups.