CAS 2327-69-7: Triethyl 4-phosphonobutyrate

Diethyl[3-(ethoxycarbonyl)propyl]phosphonate

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Triethyl 4-phosphonobutyrate (TEPB) is a synthetic drug that has been shown to be effective against the malaria parasite Plasmodium falciparum. TEPB inhibits the enzyme reductoisomerase, which is essential for the synthesis of 5-phosphate in human erythrocytes. It also prevents the synthesis of phospholipids in eukaryotic cells, including both prokaryotic and eukaryotic cells. TEPB has been shown to be effective against P. falciparum in vitro and in vivo. The drug is not active against other species of Plasmodium or other parasites such as Toxoplasma gondii or Schistosoma mansoni.