CAS 23470-00-0: 2-Palmitoylglycerol

2-Palmitoylglycerol is a monoacylglycerol that is synthesized from the breakdown of dietary fats. It is also synthesized in tissues through the action of phospholipase A2 and diacylglycerol acyltransferase. 2-Palmitoylglycerol has been shown to bind to the cannabinoid receptor type 1 (CB1), which leads to activation of peroxisome proliferator-activated receptor α (PPARα). This activation induces gene expression changes that lead to increased fatty acid oxidation and decreased triglyceride synthesis in liver cells. 2-Palmitoylglycerol has been shown to reduce body weight gain and increase insulin sensitivity in mice models on high fat diets. 2-Palmitoylglycerol has also been shown to increase butyrate, a short chain fatty acid, levels in rats with metabolic disorders.

Endogenous fatty acid glycerol ester

Applications A biomarker of metabolic responses to hepatotoxicants and carcinogens. References Broadhurst, D., et al.: Metabolomics, 2, 171 (2006), Shi, J., et al.: Nat. Biotechnol., 25, 930 (2007),

2-Palmitoylglycerol is a high quality, versatile building block that is used as a reagent and a speciality chemical. This compound can be used in the synthesis of complex compounds and as a reaction component for synthesizing valuable fine chemicals. 2-Palmitoylglycerol is also used as a building block for creating versatile scaffolds in drug development.