CAS: 2361304-26-7

STAT3-IN-3 is a small molecule that mitigates the inflammatory response by inhibiting the production of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), and has been shown to have potential for treating neurodegenerative diseases. STAT3-IN-3 has been studied in clinical trials with type 2 diabetes patients who are insulin resistant. It was found to be effective at reducing markers of inflammation and improving glucose tolerance. The mechanism of action of STAT3-IN-3 is not yet fully understood, but it appears to activate autophagy through a signalling pathway that involves the protein kinase B/Akt. This compound also may play a role in maintaining healthy collagen production and promoting lipoprotein function.

STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.